慢性阻塞性肺疾病患者影像学表型的临床治疗及疗效探究

Clinical efficacy of imaging performance in patients with chronic obstructive pulmonary disease

目的:探讨慢性阻塞性肺疾病患者影像学表型的临床治疗及疗效。方法:选择慢性阻塞性肺疾病患者76例作为研究对象,根据胸部高分辨CT将患者分为A型、M型和E型,分别给予布地奈德福莫特罗吸入剂治疗,测定患者用药前后肺功能指标、评估测试问卷评价。结果:A型患者治疗前后肺功能指标改变均具有统计学意义(P<0.05),E型患者治疗前后RV/TCL评分差异具有统计学意义(P<0.05),FEV1和FEV1% Pre差异均无统计学意义(P>0.05),M型患者治疗前后肺功能指标改变均具有统计学意义(P<0.05)。三型患者治疗前后CAT评分改变均具有统计学意义(P<0.05)。结论:A型和M型患者对激素的反应优于E型,即E型患者病情较重,肺通气明显减退,需要采取更大剂量药物对多种药物联合进行治疗。

Objective： To investigate the clinical treatment and therapeutic effect of chronic obstructive pulmonary disease （COPD） imaging phenotype. Methods： Patients with chronic obstructive pulmonary disease （COPD） in 75 cases as the research object, according to the thoracic high resolution CT, the patients were divided into type A, M type and E type were given budesonide / formoterol inhalation in the treatment, determination of pulmonary function in the patients before and after treatment, assessment test were evaluated. Results： Pulmonary function indexes before and after treatment in patients with type a change has significant difference （P 〈 0.05）, E type before and after treatment in patients with RV/TCL score difference has statistical significance （P 〈 0.05）, FEV1 and FEV1% Pre differences had no statistical significance （P 〉 0.05） and pulmonary function indexes before and after treatment in patients with M type changes were statistically significant （P 〈 0.05）. Three types before and after treatment in patients with cat score changes were statistically significant （P 〈 0.05）. Conclusion ： Patients with type A and M type of hormone response is superior to e type, that is e type patients with heavier, significantly impaired pulmonary ventilation and need to take larger doses of the drug to a variety of drugs combined therapy.