MMP-9早期诊断急性重症胰腺炎的临床价值

Clinical significance of MMP-9 value in early diagnosis of severe acute pancreatitis

目的探讨检测患者血清基质金属蛋白酶-9(MMP-9)早期诊断急性重症胰腺炎的临床价值。方法以健康体检者、非胰腺炎的急腹症患者、轻症胰腺炎(MAP)、重症胰腺炎(SAP)患者分为4个实验组,采集患者入院24 h内的血清,测定其血清中MMP-9的含量,结果进行方差分析并绘制其ROC曲线。结果 MMP-9在SAP和MAP组中明显高于正常对照组和非胰腺炎急腹症的实验对照组,差异有统计学意义;同时SAP组血清MMP-9水平明显高于MAP组,差异有统计学意义;绘制ROC曲线得出曲线下面积为0.865,最佳参考值为537.675μg/L,此时MMP-9检测SAP的敏感度为75%,特异度为83.3%。结论 MMP-9在急性胰腺炎患者中特异性升高,并且升高程度与胰腺炎的严重程度呈正相关性,当>537.675μg/L提示重症胰腺炎可能性大,有望成为预测胰腺炎炎症程度的指标。

Objective To discuss the clinical significance of MMP -9 value in early diagnosis of severe acute pancreatitis. Methods The health people, non -pancreatitis with acute abdominal pain patients, mild acute pancreatitis patients and severe acute pancreatitis were collected and divided into four groups. The serum admitted within 24 hours in hospital were collected. MMP - 9 in the serum were measured and analyzed by variance analysis and ROC curve graph. Results The serum level of MMP - 9 in the pancreatitis patients was significantly higher than the control group and non pancreatitis group. The level of MMP - 9 in SAP group was obviously higher than that of MAP group. The difference has statistical significance. The area of ROC curve graph was 0.865, the best critical value was 537. 675 μg/L,the sensitivity was 75% and the specificity was 83.3%. Conclusions MMP - 9 increases significantly in patients with acute pancreatitis, specificity compared with other acute abdominal disease and the levels associated with the severity of acute pan- creatitis. When the level of MMP- 9 is higher than 537. 675 μg/L,it＇s strong suggested SAP, which is expected to be a better index in predicting the severity of acute pancreatitis.