孕妇血清中胎盘生长因子对子痫前期及妊娠结局影响的研究

Effects of serum placental growth factor on preeclampsia and pregnancy outcome

目的研究子痫前期及正常妊娠孕妇血清中胎盘生长因子（PLGF）水平的变化，探讨PLGF与子痫前期发病的关系及对妊娠结局的影响。方法选取在某院分娩的孕妇共60例，分为轻度子痫前期（MPE组）、重度子痫前期（SPE组）及正常妊娠孕妇，每组20例。用ELISA方法测定各组孕妇PLGF水平。结果SPE组PLGF的水平较MPE组及正常妊娠组均显著降低（P〈0．05），MPE组较正常妊娠组亦显著降低（P〈0．05）。新生儿出生体重与PLGF的相关系数为0．611（P〈0．05）。结论孕妇PLGF水平随子痫前期病情发展而下降，该值可作为临床预测子痫前期病情发展及妊娠结局的监测指标。

Objective To investigate the changes of serum placental growth factor （PLGF） levels in preeclampsia and normal pregnant women, and to explore the relationship between the levels of serum PLGF and preeclampsia and the effects on pregnancy outcome. Methods A total of 60 pregnant women who chose to deliver in our hospital were enrolled in the current the study. They were divided into three groups （n = 20） ： a mild preeclampsia group （Group MPE） , a se- vere preeclampsia group （ Group SPE） , and a normal pregnancy group （ Group normal pregnancy）. Their levels of PLGF were measured by ELISA. Results Group SPE produced remarkably reduced levels of PLGF than Groups MPE and nor- mal pregnancy （P 〈 0.05 ）. Meanwhile, Groups MPE showed marked decreases in PLGF level compared with Group nor- mal pregnancy （ P 〈 0.05 ）. The correlation coefficient between neonatal birth weight and PLGF was 0.611 （ P 〈 0.05 ）. Conclusions The levels of PLGF in pregnant women decrease as preeclampsia develops, which may be used as a moni- toring index to predict the development of preeclampsia and pregnancy outcome.