DH/AOT阴阳离子药物/表面活性剂混合物理化性质及体外释药动力学研究

Study on DH/AOT Physicochemical Properties and Release Kinetics of Anion and Cation Drugs/Surfactants in Vitro

目的:研究荷电药物与相反电荷表面活性剂混合物的理化性质及体外释放。方法:通过调节DH/AOT摩尔比,阴阳离子聚集体呈现不同带电特性,结构,以及由于聚集体的结构改变可影响药物的释放行为。结果:载药阴阳离子囊泡可作为缓释的载体。结论:阴阳离子囊泡可作为一种新型的药物缓释载体。

Objective： To study the physical and chemical properties and release in vitro of charged drugs and oppositely charged surfactant mixtures. Methods： By adjusting the molar ratio of MH/AOT, the cation and cation aggregates exhibit different charging characteristics, structures and the release behavior of the drug due to the structural change of the aggregates. Results： Carrier cation and anion vesicles can be used as carriers for sustained release. Conclusion： The vesicles can be used as a new type of drug delivery carrier.