微波辅助法合成新黄酮类化合物骨架

Microwave-assisted synthesis of neoflavonoids framework

探索了一种新黄酮类化合物骨架的新的合成方法,以取代苯甲醛和丙二酸为起始原料,在哌啶的催化下生成取代苯基丙烯酸衍生物;采用微波辅助的方法,以三氟乙酸为溶剂,取代苯基丙烯酸衍生物和苯酚类化合物反应合成了新黄酮类化合物;研究了微波反应功率、反应时间等因素对产物收率的影响,并确定了优化反应条件.在最优条件下,以61%~85%的收率得到6种含不同取代基的新黄酮类化合物骨架.用MS、IR和1H-NMR对目标产物的结构进行了表征.

A new method for the synthesis of neoflavonoids framework was studied.The substituted phenylacrylic acid derivatives were prepared by substituted phenylaldehyde and malonic acid in the presence of piperidine catalyst.With trifluoroacetic acid as a solvent,neoflavonoids were synthesized via reaction between substituted phenylacrylic acid derivatives and phenols with microwave-assisted method.The effects of microwave reactive power and reaction time on the yield were investigated,and the optimal reaction condition was established.Six neoflavonoid compounds with different substituent groups were synthesized in 61%-85% yields under the optimized reaction conditions.The structures of all products were confirmed by the corresponding mass spectrum（MS）,nuclear magnetic resonance spectrum（~1H-NMR） and infrared spectroscopy（IR）.