分子靶向药物致皮肤不良反应的预防及护理

Prevention and Nursing of Cutaneous Adverse Reaction Caused by Molecular Targeted Drugs

目的探究分子靶向药物治疗非小细胞肺癌时出现皮肤不良反应的预防和护理措施。方法选取非小细胞肺癌患者84例,所有患者均采用分子靶向药物治疗,按照不同的护理方式将患者分为采用常规护理的对照组(42例),在对照组基础上同时应用针对性护理措施的观察组(42例),比较两组患者的皮肤不良反应发生率。结果经过护理,观察组Ⅲ级皮肤不良反应发生率为14.29%,低于对照组的33.33%,差异有统计学意义(P<0.05),且观察组Ⅲ级甲沟炎发生率为2.38%,明显低于对照组的26.19%,差异有统计学意义(P<0.05)。结论针对性护理方式和预防措施可降低分子靶向药物所致的皮肤不良反应发生率,提高患者生存质量,具有一定临床应用价值。

Objective To explore the prevention and nursing measures of cutaneous adverse reaction in the treatment of non-small cell lung cancer by molecular targeted drugs. Methods 84 cases of nonsmall cell lung cancer were selected. All patients were treated with molecular targeted drugs,according to the different nursing. Patients were divided into control group（ 42 cases） and the conventional care at the same time in the control group on the basis of application of targeted nursing intervention group（ 42 cases）. The adverse reactions of the two groups of patients with skin incidence were analysed. Results After nursing,the observation group level Ⅲ skin was 14. 29% incidence of adverse reactions,less than33. 33% of the control group. The difference was statistically significant（ P〈0. 05）,and the observation group level Ⅲ paronychia incidence was 2. 38%, significantly lower than the control group26. 19%. The difference was statistically significant（ P〈0. 05）. Conclusion Targeted nursing methods and preventive measures can reduce the incidence of cutaneous adverse reaction caused by molecular targeted drugs. and can improve the quality of life of patients and have a certain clinical value.