2型糖尿病细胞治疗研究进展

Research progress of cell therapy in type 2 diabetes mellitus

近年来,糖尿病发病率日益增高,胰岛B细胞功能进行性衰竭和胰岛素抵抗是导致2型糖尿病发生、发展的主要原因。现有2型糖尿病的临床治疗措施存在局限性。随着疾病的进展,较多病人虽联合多种口服降糖药甚至胰岛素干预,仍不能长期良好控制血糖和防治各种慢性并发症的目的,还存在低血糖和体重增加等风险,治疗现状不容乐观。包括胰岛细胞、干细胞移植,诱导胰岛α细胞向B细胞转化,或诱导肝细胞转化的细胞治疗为2型糖尿病治疗提供了新思路。本文对2型糖尿病的细胞治疗研究进展做一综述,希望为相关基础研究和临床研究提供参考。

The incidence of diabetes mellitus is increasing in recent years .Progressive function failure of pancreatic islet B cells and insulin resistance are the main causes of the occurrence and development of type 2 diabetes mellitus .The current treat-ment strategies for type 2 diabetes mellitus have limitations .As the disease progresses , long-term glycemic control and preven-tion of various chronic complications can not be achieved in some patients even with combined treatment of oral hypoglycemic agents and insulin intervention . Furthermore, adverse drug reactions such as hypoglycemia ,weight-gain and other risks still exist ,with this reason, the treatment of type 2 diatetes mellitus is not satisfactory .In recent years ,cell therapy including pancreatic islet cell transplan-tation ,stem cells transplantation ,inducing conversion of pancreatic islet alpha cells to B cells and inducing conversion of hepatic cells has provided new ideas for the treatment of type 2 diabetes mellitus . The research progress in cell therapy for type 2 diabetes mellitus is reviewed in this paper,so as to provide reference for related basic and clinical researches.