血脂异常与维持性血液透析患者脑卒中的相关性研究

Correlation between Dyslipidemia and Stroke in Patients undergoing Maintenance Hemodialysis

【目的】探讨血脂异常与维持性血液透析（MHD）患者脑卒中的关系。【方法】选择MHD患者120例（观察组）与同期健康体检正常人员60例（对照组），依据脑卒中发生与否将观察组患者分为脑卒中组与非脑卒中组，比较各组血脂指标。【结果】观察组甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）水平高于对照组，高密度脂蛋白胆固醇（HDL-c）低于对照组，差异有显著性（P〈0．05）；脑卒中组TG、LDL-C水平分别为（2．76±0．94）mmol／L、（3．41±0．72）mmol／L，明显高于非脑卒中组的（1．68±0．79）mmol／L、（2．75±0．73）mmol／L，且差异均有显著性（P〈0．05），而HDL—C水平两组相当（0．93±0．30VS0．98±0．25）（P〉0．05）；Lo—gistic多因素回归分析显示MHD患者脑卒中发生独立危险因素包括年龄、透析时间、透析前收缩压、TG、LDL—C水平。【结论IMHD患者年龄大、透析时间长、透析前收缩压、TG、LDL—C水平高是脑卒中发生的独立危险因素。

[Objective]To study the correlation between dyslipidemia and stroke in patients undergoing maintenance hemodialysis （MHD）.[Methods]Atotal of 120 patients undergoing MHD （observation group） and 60 cases of healthy persons （control group） were enrolled in the study. According to the occurrence of stroke, the patients were divided into stroke group and non-stroke group. The blood lipids were compared a- mong groups.[Results]Levels of triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C） and low- density lipoprotein cholesterol （LDL-C） showed significant differences between the observation group and the control group （ P %0.05）. Levels of TG and LDL-C in stroke group were （2.76±0.94） mmol/L and （3.41± 0.72） mmol/L, respectively while those in the non-stroke group were （1.68±0.79） mmol/L and （2.75±0.73） mmol/L, respectively （ P〈0.05）. Multivariate Logistic regression analysis showed that the independent risk factors for stroke in patients undergoing MHD included age, dialysis time, systolic blood pressure before dial- ysis, TG and LDL-C levels. [Conclusion]Dyslipidemia easily occur in patients undergoing MHD. Advanced age, long dialysis time, systolic blood pressure before dialysis, TG and LDL-C levels are the risk factors for the occurrence of stroke.