p2PSA及基因检测在前列腺癌预测中的应用价值研究
摘要
近年来,前列腺癌的发病率呈现出显著上升的趋势,已经成为世界上发病率最高的恶性肿瘤之一。全世界每年大约有914000例前列腺癌新发病例出现,并且该疾病的死亡率较高。相对于其他国家,虽然前列腺癌在我国的发病率较低,但是该疾病的发病率也显著上升,对人们的身体健康造成了严重威胁。经过长期临床实践发现,有效治疗前列腺癌的关键在于及早对其进行准确诊断。本研究主要针对p2PSA及基因检测在前列腺癌预测中的应用价值进行探究。
二级参考文献30
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1刘秉乾,武玉东,魏金星,张彤,刘冉录,马腾骧.前列腺癌组织中前列腺癌抗原-1的表达及临床意义[J].中华男科学杂志,2007,13(11):997-1001. 被引量:4
-
2Kirby RS,Fitzpatrick JM,Irani J.Prostate cancer diagnosis in the new millennium:Strengths and weaknesses of prostate-specific antigen and the discovery and clinical evaluation of prostate cancer gene 3(PCA3).BJU Int,2009,103(4):441-445.
-
3Crawford ED,Leewansangtong S,Goktas S,et al.Efficiency of prostate-specific antigen and digital rectal examination in screening,using 4.0 ng/ml and age-specific reference range as a cutoff for abnormal values.Prostate,1999,38(4):296-302.
-
4Pinsky PF,Andriole GL,Kramer BS,et al.Prostate biopsy following a positive screen in the prostate,lung,colorectal and ovariancancer screening trial.J Urol,2005,173(3):746-750.
-
5Catalona WJ,Bartsch G,Rittenhouse HG,et al.Serum pro-prostate specific antigen preferentially detects aggressive prostate cancers in men with 2 to 4 ng/ml prostate specific antigen.J Urol,2004,171(6 Pt 1):2239-2244.
-
6Khan MA,Sokoll LJ,Chan DW,et al.Clinical utility of pro PSA and"benign"PSA when percent free PSA is less than 15%.Urology,2004,64(6):1160-1164.
-
7Mikolajczyk SD,Marker KM,Millar LS,et al.A truncated precursor form of prostate specific antigen is a more specific serum marker of prostate cancer.Cancer Res,2001,61(18):6958-6963.
-
8Sokoll LJ,Wang Y,Feng Z,et al.[-2]proenzyme prostate specific antigen for prostate cancer detection:A National Cancer Institute early detection research network validation study.J Urol,2008,180(2):539-543.
-
9Le BV,Griffin CR,Loeb S,et al.[-2]proenzyme prostate specific antigen is more accurate than total and free PSA in differentiating prostate cancer from benign disease in a prospective prostate cancer screening study.J Urol,2010,183(4):1355-1359.
-
10Mearini L,Ferri C,Lazzeri M,et al.Evaluation of prostate-specific antigen isoform p2PSA and its derivates,%p2PSA,prostate health index and prostate dimension-adjusted related index in the detection of prostate cancer at first biopsy:An exploratory,prospective study.Urol Int,2014,93(2):135-145.
共引文献4
-
1许振,刁统祥,臧振杰,邵丁昌,张奇,孙鼎琪,傅强.前列腺特异性抗原同源异构体2及其衍生指标在前列腺癌诊断中的价值[J].山东大学学报(医学版),2022,60(6):51-56. 被引量:3
-
2张倩,靳丽亚.血清p2PSA检测在前列腺癌诊断中的临床应用价值[J].现代泌尿生殖肿瘤杂志,2019,11(5):278-282. 被引量:5
-
3宋丽娜,令狐志宏,于珊珊.前列腺癌生物标志物的研究进展[J].中华实验外科杂志,2023,40(11):2426-2428.
-
4江唯,黄雅为,冯梦婷,谢超,李志华,方亮,汪建焜.前列腺特异性抗原同源异构体2及其衍生物对血清前列腺特异性抗原4~10μg/L前列腺病变患者的临床诊断价值[J].当代医学,2024,30(13):10-14.
-
1罗冬梅,吴顺华,王凯.新疆巴州地区梅毒的动力学建模与仿真[J].中华地方病学杂志,2017,36(7):542-546. 被引量:2
-
2兰光,孙建云,董锟,吕卫民,张阳,申艳琴.非脱羧勒克菌脉冲场凝胶电泳分子分型方法建立[J].疾病预防控制通报,2017,32(4):68-70.