血中PCT和中性粒细胞CD64水平与肾病综合征患者激素治疗效果及并发症的关系

Relationship between serum levels of PCT and neutrophil CD64 with effect of hormone therapy and complications in patients with nephrotic syndrome

目的探讨血中PCT和中性粒细胞CD64水平与原发性肾病综合患者激素治疗效果及并发症的关系。方法选择2015年9月至2016年9月65例原发性肾病综合征患者作为研究对象,所有原发性肾病综合征患者均采用激素治疗,检测患者血中PCT和CD64水平与肾病综合征治疗效果及临床并发症的关系。结果根据PCT和中性粒细胞CD64水平中位数分为高水平组和低水平组,结果发现PCT和中性粒细胞CD64高水平和低水平组患者血清中血肌酐、蛋白、尿蛋白以及病理类型对比无差异,高水平PCT患者激素敏感为15例明显低于低水平组21例,高水平中性粒细胞患者激素敏感为14例,高水平PCT患者急性肾衰竭、感染、血栓分别为8、10、6例,明显高于低水平组患者,高水平中性粒细胞CD64水平急性肾衰竭、感染、血栓分别为7、11、6例明显高于低水平组患者,差异有统计学意义(P<0.05)。结论血清中PCT和中性粒细胞CD64水平与肾病综合征患者激素治疗效果及临床预后明显相关。

Objective To investigate the relationship between serum levels of PCT and neutrophil CD64 contents with the effect of hormone therapy and complications in the patients with primary nephrotic syndrome.Methods Sixty-five patients with primary nephrotic syndrome in our hospital from September 2015 to September 2016 were selected as the research subjects,all cases were treated with hormonal therapy,the serum levels of PCT and neutrophil CD64 were detected and their relationship with the curative effect and complications of nephrotic syndrome was analyzed.Results According to the PCT and neutrophil CD64 median levels,the cases were divided into the high level group and low level group,the results found that serum creatinine,serum protein,urine protein and pathological types had no statistical difference between the high level group and low level group.The hormone sensitivity had 15 cases in the patients with high PCT level,which was significantly lower than 21 cases in the patients with low PCT level;the hormone sensitivity had 14 cases in the patients with high neutrophil CD64 level,acute renal failure,infection and thrombus in the patients with high PCT level had 8,10,6 cases,which were significantly lower than those in the patients with low PCT level;acute renal failure,infection and thrombus in the patients with high neutrophil CD64 level had 7,11,6 cases,which were significantly higher than those in the patients with low neutrophil CD64 level （P〈0.05）.Conclusion The levels of serum PCT and neutrophil CD64 are significantly correlated with the therapeutic effect and clinical prognosis in the patients with nephrotic syndrome.