血清胃功能检测在早期胃癌筛查中的临床应用研究

Clinical application of serum gastric function detection in early gastric cancer screening

目的探讨血清胃功能检测在早期胃癌筛查中的临床应用价值。方法选取该院2015年12月至2016年12月收治的42例胃癌患者、75例胃部良性疾病患者、44例健康体检者为研究对象,所有被研究对象均进行胃镜检查,同时行镜下活检术,并按要求抽血化验,检测胃功能相关指标:胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ、胃泌素17(G17)及幽门螺杆菌(HP)。分析4组研究对象的血清胃功能指标的情况。结果 PGⅠ,PGⅠ/PGⅡ的表达,从低到高,分别是胃癌组、萎缩性胃炎组、胃溃疡组、浅表性胃炎组和对照组,且两两相比,差异均有统计学意义(P<0.05);对照组的G17低于胃溃疡组、萎缩性胃炎组、胃癌组,胃溃疡组的G17低于胃癌组,差异有统计学意义(P<0.05)。对照组的HP阳性率低于浅表性胃炎组,浅表性胃炎组低于胃溃疡组,胃溃疡组低于萎缩性胃炎组,萎缩性胃炎组低于胃癌组,差异均有统计学意义(P<0.05)。结论血清胃功能检测能较好地区分胃部良性病变与恶性病变,可作为早期筛查的重要指标,且易于接受、成本低,对于检测结果阳性者,应进行胃镜下检查,以提高早期诊断率。

Objective To investigate the clinical application value of serum gastric function detection in early gastric cancer screening.Methods Forty-two cases of gastric cancer,75 cases of benign gastric diseases and 44 individuals undergoing normal physical examination in our hospital from December 2015 to December 2015 were selected as the research subjects,performed the gastroscopic examiantion,simultaneously conducted the microscopic biopsy,and extracted blood for conducting the related indexes detection of gastric function,including pepsinogen Ⅰ （PG Ⅰ）,pepsinogen Ⅱ （PG Ⅱ）,PG Ⅰ/PG Ⅱ,gastrin 17 （G17） and helicobactor pylori（HP）.Serum gastric function situation in the research subjects of 4 groups was studied.Results PG Ⅰ and PG Ⅰ/PG Ⅱ expressions from low to high were gastric cancer group,atrophic gastritis group,gastric ulcer group,superficial gastritis group and normal group respectively,the pairwise comparison had statistical difference （P〈0.05）;G17 in the normal group was lower that that in gastric ulcer group,atrophic gastritis group and gastric cancer group G17 in the gastric ulcer group was lower than that in the gastric cancer group,the differences were statistically significant （P〈0.05）.The HP positive rate in the normal group was lower than that in the superficial gastritis group,the superficial gastritis group was lower than the gastric ulcer group,the gastric ulcer group was lower than the atrophic gastritis group,and the atrophic gastritis group was lower the gastric cancer group,the differences had statistical significance （P〈0.05）.Conclusion Serum gastric function detection can better distinguish gastric benign lesions from malignant lesions,and can serve as an important indicator of early screening,which is easy to accept with low cost,for the patients with positive results,the gastroscopic examination should be conducted in order to improve the early diagnostic rate.