表皮生长因子受体联合D-二聚体检测对良、恶性胸腔积液的诊断

Diagnosis of benign and malignant pleural effusion with epidermal growth factor receptor and D-dimmer

目的:探讨表皮生长因子(EGFR)受体联合D-二聚体检测对良恶性胸腔积液的诊断价值。方法:分别用ELISA法和免疫浊度法检测胸腔积液中表皮生长因子(EGFR)和D-二聚体的含量,并对结果进行统计学分析。结果:恶性质胸腔积液表皮生长因子(EGFR)和D-二聚体的含量分别为(739.3±114.2)pmol/L和(948.26±410.60)μg/L,良性胸腔积液表皮生长因子(EGFR)和D-二聚体的含量分别为(410.8±87.1)pmol/L和(467.22±199.65)μg/L,两者差异无统计学意义(P<0.05)。结论:胸腔积液中表皮生长因子(EGFR)和D-二聚体的定量检测对良、恶性胸腔积液的鉴别诊断具有一定的价值。

Objective To investigate the diagnostic value of epidermal growth factor receptor（ EGFR） receptor combined with D-dimer in the diagnosis of benign and malignant pleural effusion. Method The contents of epidermal growth factor receptor（ EGFR） and D-dimer were detected by ELISA and immune turbidimetry respectively. Results Malignant pleural effusion epidermal growth factor（ EGFR） and the content of D-dimer were（ 739. 3 ± 114. 2） pmol/L and（ 948. 26 ± 410. 60） μg/L,respectively,benign pleural effusion epidermal growth factor（ EGFR） and the content of D-dimer were（ 410. 8 ± 87. 1） pmol/L and（ 467. 22 ± 199. 65） μg/L,respectively,both with significant differences（ P 〈 0. 05）. Conclusion Quantitative detection of epidermal growth factor receptor（ EGFR） and D-dimer in pleural effusion is valuable for differential diagnosis of benign and malignant pleural effusion.