红细胞分布宽度对良性前列腺增生症患者合并代谢综合征的预测作用

Alter red blood cell distribution width in benign prostatic hyperplasia patients with metabolic syndrome

目的:探讨红细胞分布宽度(RDW)对良性前列腺增生症(BPH),尤其是合并代谢综合征(MS)严重程度的预测价值。方法:回顾性分析诊断的426例BPH患者,分为合并MS组和无MS组,另外69例无BPH及MS患者作为对照组。收集临床一般资料,检测RDW、血糖、三酰甘油、胆固醇、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDLC)、血红蛋白、白细胞、C-反应蛋白(CRP)和前列腺特异性抗原(PSA)等。结果:33.8%BPH患者合并MS,BPH组RDW水平显著高于对照组,差异有统计学意义([(13.3±0.8)%与(12.6±0.8)%,P<0.001])。此外,在BPH患者中,与无MS组比较,合并MS组RDW水平升高,差异具有统计学意义[(13.8±0.6)%与(13.0±0.6)%,P<0.001]。总前列腺体积(TPV)和残余尿量(PVR)在BPH合并MS组中升高,和MS组分个数相关(r=0.251,P<0.001和r=0.275,P<0.001)。在MS组分中,三酰甘油以及HDL-C水平和前列腺体积相关(r=0.373,P<0.001和r=-0.425,P<0.001)。RDW和TPV(r=0.370,P<0.001)、体重指数(BMI)(r=0.367,P<0.001)以及MS(r=0.276,P<0.001)正相关。MS患者多因素Logistic回归分析显示,高血压、糖尿病、BMI和RDW是MS患者的独立预测因素。结论:MS和BPH相关,RDW水平在BPH,特别是合并了MS患者中升高。在BPH患者中,RDW是MS独立的预测因子之一。

Objective To investigate the association of serum red blood cell distribution width（ RDW） levels with the severity of benign prostatic hyperplasia（ BPH）,especially in BPH patients with metabolic syndrome（ MS）. Method 426 Men with BPH were recruited into the study. The BPH patients were classified as MS group and non-MS group. 69 patients without BPH and MS were as the control group. General clinical data were collected. The level of RDW,glucose,triglyceride,cholesterol,high density lipoprotein-cholesterol（ HDL-C）,low density lipoprotein-cholesterol（ LDL-C）,hemoglobin,white blood cell,C-reactive protein（ CRP） and prostate-specific antigen（ PSA） were measured. Results MS was diagnosed in 33. 8% of the BPH patients. The RDW values were found to be higher in the BPH group than in the control group [（ 13. 3 ± 0. 8） % vs.（ 12. 6 ±0. 8） %,P 〈 0. 001]. In addition,in BPH patients,RDW values were higher in MS group than in non-MS group [（ 13. 8 ±0. 6） % vs.（ 13. 0 ± 0. 6） %,P 〈 0. 001]. The total prostate volume（ TPV） and postvoid residual（ PVR） urine volume were significantly higher in subject with MS than in non-MS and related with the number of metabolic abnormalities（ r = 0. 251,P 〈0. 001,and r = 0. 275,P 〈 0. 001）. Serum triglyceride and HDL-C levels were significantly associated with TPV（ r = 0. 373,P〈 0. 001,and r =-0. 425,P 〈 0. 001）. There was a significant correlation between RDW and TPV（ r = 0. 370,P 〈 0. 001）,Body mass index（ BMI）（ r = 0. 367,P 〈 0. 001） and MS（ r = 0. 276,P 〈 0. 001）. In multivariate Logistic regression analysis,hypertension,diabetes,BMI,and RDW were observed to be independent predictors for MS. Conclusion MS is associated with BPH development in men. The RDW level is significantly higher in patients with BPH than that in control. RDW is an independent predictor of MS in BPH patients.