多奈派齐联合丁苯酞对提高血管性痴呆患者认知功能及生活能力的效果分析

Analysis of curative effect of donepezil combined with butylphthalide on cognitive function in patients with vascular dementia and life ability

目的:探究血管性痴呆患者以多奈派齐联合丁苯酞治疗的临床疗效。方法:选取60例血管性痴呆患者为研究对象,采用随机分组法分为治疗组与对照组,各30例,分别采用多奈派齐联合丁苯酞和仅使用多奈派齐治疗,其他治疗措施相同,两周后,观察两组间的疗效及相关指标差异。结果:在疗效方面治疗组总有效率大于对照组,差异有统计学意义(P<0.05),同时两组治疗后的(MMSE)和(ADL)较治疗前均有显著改善,且治疗组改善程度较对照组更为明显,差异有统计学意义(P<0.05)。结论:血管性痴呆患者采用多奈派齐联合丁苯酞治疗效果明显,值得推广。

Objective To explore in Donepezil Hydrochloride joint Butylphthalide treatment in patients with vascular dementia clinical curative effect. Method 60 patients with vascular dementia were selected as object of study,they were randomly divided into treatment group and control group,each group of 30 people,with Donepezil Hydrochloride joint Butylphthalide and only use Donepezil Hydrochloride treatment,other treatments,the same two weeks later,observation curative effect and the related indicators of the differences between two groups. Results Curative effect in treatment group,the total effective rate was greater than that in control group（ P 〈 0. 05）,at the same time,the two groups after treatment（ MMSE） and（ ADL） were significantly improved than before treatment,and the degree of treatment group improved more significantly than the control group with significant difference（ P 〈 0. 05）. Conclusion Vascular dementia patients using Donepezil Hydrochloride joint Butylphthalide treatment effect is obvious,it is worth promoting.