不同提取工艺孕康口服液对先天性、习惯性流产药理作用的比较

Pharmacological actions of Yunkang oral liquid prepared by different extraction processes on congenital and habitual abortion:a comparative analysis

目的:考察几种采用不同提取工艺制备的孕康口服液对小鼠先天性、习惯性流产的药理药效作用,为孕康口服液制剂工艺改革提供依据。方法:通过建立相关药理模型,考察几种采用不同提取工艺制备的孕康口服液对小鼠凝血时间、出血时间及己烯雌酚所致小鼠流产的保胎作用的影响。结果:改进工艺制备孕康口服液A、B可缩短实验小鼠凝血止血时间,对己烯雌酚所致流产模型具有保胎作用,疗效优于原工艺制备的孕康口服液、孕康胶囊和阳性对照药保胎灵片。结论:本研究为孕康口服液制剂工艺改革提供了实验依据。

Objective： To investigate the pharmacological actions of Yunkang oral liquid prepared by different extraction processes on congenital and habitual abortion,and to provide a basis for the innovation of the preparation process for Yunkang oral liquid. Methods： Related pharmacological models were established to investigate the effect of Yunkang oral liquid prepared by different extraction processes on clotting time,bleeding time,and abortion induced by diethylstilbestrol in mice. Results： Yunkang oral liquid A and B prepared by modified processes shortened the clotting time in experimental mice and helped to prevent abortion induced by diethylstilbestrol. Moreover,it had a significantly better clinical effect than Yunkang oral liquid prepared by original process,Yunkang capsules,and the positive control drug Baotailing tablets. Conclusion：This study provides an experimental basis for the innovation of the preparation process for Yunkang oral liquid.