特异性和非特异性免疫细胞在COPD发病机制中的作用

Role of specific and non-specific immune cells in the pathogenesis of chronic obstructive pulmonary disease

COPD是一种暴露于有害气体或颗粒而导致的持续性气流受限，呈进行性发展，不完全可逆的慢性气道及肺部炎症。COPD是许多炎症通路介导的复杂病理过程，是成年人发病及病死的主要原因之一。巨噬细胞、中性粒细胞、树突状细胞、CD8＋T和CD4＋T细胞亚群是COPD发病过程中的主要炎症细胞，这些炎症细胞与人体疾病研究还不清楚，是如何参与宿主防御，免疫调节和自身免疫作用有待进一步研究。本文旨在对各种炎症细胞及在COPD免疫机制中的作用作一综述。

Chronic obstructive pulmonary disease （COPD） is a chronic and progressive inflammatory disease of the airways and lungs that results in limitations of continuous airflow and is caused by exposure to noxious gasses and particles. A major cause of morbidity and mortality in adults, COPD is a complex disease pathologically mediated by many inflammatory pathways. Macrophages, neutrophils, dendritic cells, CD8＋T CD4＋ T-lymphocytes are the key inflammatory cells involved in COPD. However, it is little understood about associations among the inflammatory cells, what role they piay in host defense, immune adjustment and automatic immune function remains to be further study. Here, we aim to review the role of each inflammatory cell and their involvement in the immunopathogenesis of COPD.