35例获得性反应性穿通性胶原病分析

Clinical and pathological analyses of 35 cases with acquired reactive perforating collagenosis

本文对2013-2016年我院35例获得性反应性穿通性胶原病临床资料和组织病理进行回顾性分析,其中男女比例为1∶1.19,平均发病年龄49.5岁,病程长短不一,临床皮损形态多样,组织病理均可见胶原纤维穿出表皮,20%患者伴有系统性疾病,临床误诊率为77%,最易误诊为结节性痒疹(13例次)和湿疹(10例次)。

Clinical and pathological data of 35 cases with acquired reactive perforating collagenosis collected from 2013 to 2016 was retrospectively analyzed. The ratio of male to female was 1 ∶ 1.19. The average age at onset of the disease was 49.5 years. The duration of the disease was diverged significantly. The histopathology shows collagen fibers within the epidermis. Only 20% of the patients were found having systemic disease. The skin lesions were diverse. The misdiagnosis rate was 77% and the disease was most misdiagnosed as prurigo nodularis（ 13 times） and eczema（ 10 times）.