摘要
炎症反应在脑缺血再灌注损伤机制中十分重要，而脑内小胶质细胞的激活是炎症反应中的重要环节。在脑缺血再灌注损伤过程中，小胶质细胞被激活，并对神经细胞发挥了损伤与保护双重作用。小胶质细胞对脑缺血再灌注损伤机制作用的复杂性，使其在脑缺血再灌注损伤研究中的意义也越来越受到重视。研究从小胶质细胞在脑缺血再灌注损伤后被激活参与炎症反应，与活化的小胶质细胞自身对脑缺血再灌注损伤的作用对小胶质细胞在脑缺血再灌注损伤中的双重作用很有意义。
Inflammatory reaction plays an important role in the mechanism of cerebral ischemia-reper- fusion injury, and the activation of microglia in the brain is an important link in the inflammatory response. In the process of cerebral ischemia-reperfusion injury, microglias are activated, and these cells play a dual role in both neural cells injury and protection. The complexity of the effect of microglia on the mechanism of cerebral is- chemia-reperfusion injury makes it more and more meaningful for the research. In this review, the dual role of microglial in cerebral ischemia-reperfusioninjury were discussed, from the perspective of microglia involved in inflammatory response and the role of microglia in cerebral ischemia-reperfusioninjury.
出处
《国际免疫学杂志》
CAS
2017年第4期416-419,共4页
International Journal of Immunology
基金
国家自然科学基金（31371079）
黑龙江省自然科学基金项目（H2015008）
