摘要
伊伐布雷定作为一种选择性If电流阻滞剂，不仅可以降低心率、改善心功能，还具有抑制炎症反应、抑制心肌重构、抗氧化应激等作用。这些作用均涉及到免疫学相关机制，由免疫细胞、炎症因子共同参与完成。伊伐布雷定可抑制动脉粥样硬化斑块形成，改善内皮功能紊乱、抑制心机重构、降低Ⅰ型纤溶酶原激活物抑制因子（plasminogen activator inhibitor，PAI-1）水平，对病毒性心肌炎和糖尿病小鼠的心脏具有保护作用。
Ivabradine is a selective If-channel blocker. Ivabradine not only reduces heart rate and im- proves heart function, but also inhibits inflammatory response, suppress myocardial remodeling, prevents oxida- tive stress, and so on. These mechanisms are involved in the immune response, immune cells, and inflammatory factors. Ivabradine could inhibit atherosclerosis plaque formation,improve endothelial dysfunction, suppress myo- cardial remodeling,and reduce Plasminogen activator inhibitor （PAI-1）. It also show cardioprotecive effect in the mice with viral myocarditis diabeetes. This review mainly discusses the immune mechanisms that underline the effect of ivabradine in cardiovascular disease.
出处
《国际免疫学杂志》
CAS
2017年第4期420-423,共4页
International Journal of Immunology
基金
国家自然科学基金面上项目（81270310）
黑龙江省教育厅海外学人重点项目（1252H0013）
哈尔滨医科大学于维汉青年基金（3010001000005）
关键词
伊伐布雷定
炎症因子
免疫应答
Ivabradine
Inflammatory factors
Immune response
