小胶质细胞自噬在阿尔茨海默病中的作用

Microglia autophagy in Alzheimer＇s disease

阿尔茨海默病（Alzheimer’s disease，AD）是一种以渐进性记忆力和认知能力减退为特征的中枢神经系统退行性疾病。自噬（autophagy）是机体一种重要的防御和保护机制。先前的研究主要集中于神经元自噬在神经退行性疾病中的作用。新近研究表明，小胶质细胞自噬影响其吞噬淀粉样蛋白，凋亡细胞和髓磷脂碎片的作用，调控炎症反应，进而调节AD病理进程。小胶质细胞自噬的研究将为AD的病理机制研究提供新思路。

Alzheimer＇s disease （AD） is a central nervous system degenerative disease,which is charac- terized by progressive memory and cognitive decline. Autophagy is an important defense and protection mecha- nism for the body. Previous studies have focused on the role of neuronal autophagy in neurodegenerative disea- ses. However,recent studies have shown that microglia autophagy affect the phagocytosis of amyloid, apoptotic cells and myelin fragments, and then regulate inflammation and the pathogenesis of AD. The study on microglia autophagy may provide new ideas for understanding the of pathology of AD.