多发性硬化与B淋巴细胞趋化因子-1

CXCL-13 and multiple sclerosis

多发性硬化（MS）是一种中枢神经系统炎症性疾病，其病理机制主要包括神经变性及炎症反应，而B淋巴细胞趋化因子-13（CXCL-13）被认为参与MS等自身免疫和炎症性疾病的发病过程。CXCL-13既通过与CXCR5结合表达于B淋巴细胞、辅助性T细胞等，又影响B细胞从而促进自身免疫反应并参与炎症反应，这为MS治疗的新型药物研究提供了理论基础。

Multiple sclerosis （MS） is an inflammatory disease of the central nervous system, in which neurodegenerative processes and inflammation play am important role in the pathogenesis of MS. CXCL-13 acts through CXCR5 receptor expressed on B lymphocytes, Th cells. CXCL-13contributes to the development of auto- immune and inflammatory disorders through influencing B cells. Understanding the role of CXCL-13 might pro- vide the fundamental basis for the discovery of new drugs to treat MS.