艾灸加独活寄生汤对中老年膝关节炎患者hs-CRP、IL-1β和TNF-α的影响(英文)

Effect of moxibustion plus Duhuo Jisheng decoction on hs-CRP,IL-1β and TNF-α levels in middle-aged and elderly patients with knee osteoarthritis

目的:探讨艾灸联合独活寄生汤对中老年膝骨性关节炎(KOA)患者血清超敏C-反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)水平的影响,并观察临床疗效。方法:共纳入90例KOA患者,按随机数字表法分为观察组和对照组,每组45例。对照组予以口服独活寄生汤治疗,观察组在对照组治疗的基础上加用艾灸治疗,观察两组患者治疗前后炎性因子hs-CRP、IL-1β和TNF-α水平的变化并比较其临床疗效。结果:治疗前两组患者的hs-CRP、IL-1β和TNF-α水平均无统计学差异(均P>0.05)。治疗8星期后,两组的hs-CRP、IL-1β和TNF-α水平均明显下降(P<0.01或P<0.05),且观察组下降幅度较对照组更明显(均P<0.05)。观察组总有效率97.8%,明显优于对照组的86.7%(P<0.05)。结论:艾灸联合独活寄生汤治疗中老年KOA具有良好的临床疗效,其机理可能与降低患者的炎性因子hs-CRP、IL-1β和TNF-α有关。

Objective： To observe the clinical effect of moxibustion combined with Duhuo Jisheng decoction for middle-aged and elderly patients with knee osteoarthritis（KOA） and its impact on serum high sensitive C-reactive protein（hs-CRP）,interleukin-1β（IL-1β） and tumor necrosis factor-α（TNF-α） levels.Methods： A total of 90 eligible KOA patients were randomized into an observation group（n=45） and a control group（n=45）.Cases in the observation group received moxibustion plus oral administration Duhuo Jisheng decoction, while cases in the control group received Duhuo Jisheng decoction. Then the hs-CRP, IL-1β and TNF-α levels were examined and the clinical effect was evaluated.Results： Before treatment, the hs-CRP, IL-1β and TNF-α levels showed no between-group statistical differences（all P〉0.05）. After 8 weeks of treatment, the hs-CRP, IL-1β and TNF-α levels all dropped significantly in both groups（P〈0.01 or P〈0.05）, and the treatment group showed more substantial changes than the control group（all P〈0.05）. The total effective rate was 97.8% in the treatment group, versus 86.7% in the control group, showing a statistical difference（P〈0.05）.Conclusion： Moxibustion plus Duhuo Jisheng decoction has a good clinical effect for middle-aged and elderly KOA patients,and the effect may relate to the decreased hs-CRP, IL-1β and TNF-α levels.