肿瘤标志物检测在肺癌诊断中的临床价值

Clinical Value of Tumor Marker Test in Diagnosis of Lung Cancer

目的:探讨四项肿瘤标志物癌胚抗原(CEA)、肿瘤相关抗原199(CA199)、肿瘤相关抗原125(CA125)和神经特异性烯醇化酶(NSE)单项检测及联合检测在早期肺癌中的诊断意义。方法:选取2016年1月~2017年1月我院收治的121例肺癌患者设为肺癌组,选取同期在我院进行治疗的85例良性肺病变患者设为病变组,以及46例在我院体检的健康体检者设为对照组,通过测量血清中CEA、CA199、CA125和NSE的表达水平,分析其在肺癌诊断中的临床价值。结果:肺癌组患者四项标志物的表达水平均显著高于病变组(P<0.05):病变组与对照组比较,差异无统计学意义(P>0.05);肺癌组CEA、CA199、CA125和NSE单项诊断灵敏度低于联合诊断(P<0.05)。结论:血清中肿瘤标记物CEA、NSE表达水平与肺癌的病理组织学类型相关,联合检测对于早期肺癌的诊断有重要意义,有助于提高患者的治疗效果。

Objective： To investigate the clinical value of CEA, CA199, CA125 and NSE single and combined detection in diagnosis of lung cancer. Methods： 121 cases of patients with lung cancer who were admitted to our hospital from Jan 2016 to Jan 2017 were included in lung cancer （LC） group, 85 cases of patients with benign lung diseases in benign disease （BD） group and 46 cases of healthy volunteers in control group, detected the expression levels of serum CEA, CA 199, CA 125 and NSE to analyze their clinical value in diagnosis of lung cancer. Results： The expression levels of the 4 markers of LC group were significantly higher than those of BD group （P〈0.05）; there was no statistical difference between BD group and control group （P〉0.05）; the sensitivity of CEA, CA199, CA125 and NSE single detection was lower than that of combined detection （P〈0.05）. Conclusion： The expression levels of serum tumor markers CEA and NSE is associated with histopathological types of lung cancer, combined detection is important to the diagnosis of early stage of lung cancer, which is helpful to improve the therapeutic effect.