银杏黄酮苷与复方丹参片对冠心病心绞痛患者心电图、心功能、血液流变学的影响对比分析

Comparative Analysis of the Effects of Ginkgo Flavone Glycosides and Compound Danshen Tablets on Electrocardiogram,Cardiac function and Hemorheology in Patients with Coronary Heart Disease Angina

目的:对比分析银杏黄酮苷与复方丹参片对冠心病心绞痛患者心电图、心功能、血液流变学的影响。方法:对我院在2015年1月至2016年12月期间新疆医科大学第六附属医院收治的冠心病心绞痛患者88例的临床治疗进行回顾性分析。采用随机抽样的方式将患者分成观察组与对照组,每组44例。对照组患者予以复方丹参片治疗,观察组患者予以银杏黄酮苷治疗,2组患者共治疗1个月,观察2组患者治疗前后心电图、心功能、血液流变学改善情况以及有无发生不良反应情况。结果:治疗后观察组患者一般症状改善总有效率、心绞痛疗效、心电图疗效均高于对照组,差异有统计学意义(P<0.05);治疗前2组患者心功能各指标比较差异无统计学意义(P>0.05),治疗后心功能各指标均有改善情况,但观察组患者改善情况明显优于对照组,差异有统计学意义(P<0.05);治疗前2组患者全血低切黏度、全血高切黏度、血浆高切黏度、红细胞压积、红细胞聚集指数比较差异无统计学意义(P>0.05),治疗后2组患者全血低切黏度、全血高切黏度、血浆高切黏度、红细胞压积、红细胞聚集指数值均有改善,但观察组患者改善程度明显大于对照组,差异有统计学意义(P<0.05);2组患者治疗期间未发生明显不适情况。结论:银杏黄酮苷治疗冠心病心绞痛的临床疗效明显优于复方丹参片,并且安全性高,更适合临床应用。

Objective： To observe the effects of Ginkgo flavone glycosides and compound Danshen tablets on electrocardiogram,cardiac function and hemorheology in patients with coronary heart disease angina. Methods： Eighty-eight patients with coronary heart disease angina in our hospital from January 2015 to December 2016 were retrospectively analyzed. Patients were divided into observation group and control group by random sampling（ 44 cases in each group） according to the different admission time sequence. The control group was treated with Compound Danshen tablet and patients in observation group were given ginkgo flavone glycosides treatment for 1 months. The ECG,heart function,improvement of blood rheology and adverse reaction in two groups were observed. Results： After treatment,the improvement ratio of general symptoms,angina pectoris,ECG curative effect in the observation group were higher than those of the control group（ P 0. 05）. Before treatment,the heart function indexes between the two groups showed no significant difference（ P 0. 05）. After treatment,the cardiac function indexes were improved in two group,but the improvement of observation group were significantly higher than that of the control group（ P 0. 05）. Before treatment,the whole blood high viscosity,whole blood low viscosity,plasma viscosity,hematocrit,erythrocyte aggregation index between two groups of patients were of no significant difference（ P 0. 05）. After treatment,the whole blood low viscosity,whole blood high shear viscosity,plasma viscosity,hematocrit,erythrocyte aggregation the index values were improved,and the improvement in the observation group were more significant than those of the control group（ P 0. 05）. There was no obvious complications between two groups during treatment. Conclusion： The clinical curative effect of Ginkgo flavone glycoside in the treatment of coronary heart disease angina pectoris is better than that of Compound Danshen tablet. Besides,it is safe and suitable for clinical application.