定喘止咳汤联合布地奈德混悬剂治疗婴幼儿喘息性支气管炎的疗效与安全性分析

Effect and Safety of Dingchuan Zhike Decoction with Budesonide Suspension in Treating Infantile Asthmatic Bronchitis

目的:研究定喘止咳汤联合布地奈德混悬剂治疗婴幼儿喘息性支气管炎的疗效与安全性。方法:将2014年9月至2016年9月期间琼海市中医院儿科收治的喘息性支气管炎婴幼儿患者98例,随机分成观察组与对照组,每组49例,观察组采用定喘止咳汤联合布地奈德混悬剂治疗,对照组采用布地奈德混悬剂治疗,比较2组的疗效、症状缓解时间以及不良反应等。结果:观察组以及对照组治疗7 d后的总有效率分别为95.92%和83.67%,观察组明显的高于对照组,差异有统计学意义(P<0.05);观察组患儿气喘、咳嗽以及肺部哮鸣音等临床症状的消失时间明显的短于对照组,差异有统计学意义(P<0.05);治疗后,观察组的Rrs SO明显低于对照组,Crs SO明显高于对照组,差异有统计学意义(P<0.05);观察组患儿3个月的复发率明显的低于对照组,比较差异有统计学意义(P<0.05)。结论:定喘止咳汤联合布地奈德混悬剂促进了临床症状缓解,提高了治疗总有效率,降低了复发率,安全性高。

Objective： To study the effect and safety of Dingchuan Zhike decoction combined with budesonide suspension in treating infantile asthmatic bronchitis. Methods： A total of 98 infants and children with asthmatic bronchitis who received treatment from September 2014 and September 2016 were included and randomly divided into observation group and control group. The treatment group was treated with Dingchuan Zhike Decoction and budesonide suspension,while the control group was only treated with budesonide suspension. The efficacy,symptom relief time and adverse reactions were compared between the two groups. Results：The total effective rate of the observation group and the control group was 95. 92% and 83. 67% respectively after 7-day treatment and the one of the observation group was significantly higher,which showed that there was significant difference（ P 0. 05）. The time asthma,cough and lung wheezing disappearance in the observation group was shorter than those in the control group（ P 0. 05）. The Rrs SO in the observation group was significantly lower than that of the control group after the treatment and Crs SO was significantly higher than the control group,with significant difference（ P 0. 05）. The recurrence rate in the observation group was significantly lower than that in the control group during the 3-month follow-up（ P 0. 05）. Conclusion： Dingchuan Zhike Decoction combined with budesonide suspension may improve relieving clinical symptoms,improve the therapeutic effect and reduce the recurrence rate,with high safety.