冠心静胶囊对心梗后抑郁模型大鼠行为学表现及5-HT的影响

Effects of Guanxinjing Capsule on Behavioral Manifestations And Level of 5-hydroxytryptamine in Post-myocardial Infarction Depression Model Rats

目的:观察冠心静对心梗后抑郁模型大鼠行为学的影响。方法:通过冠状动脉结扎后进行慢性轻度不可预见性刺激制造心梗后抑郁模型,测定治疗前后大鼠行为学指标以及5-羟色胺(5-hydroxytryptamine,5-HT)变化。结果:模型组大鼠治疗后水平及垂直运动分值、体重、液体消耗及糖水偏爱,5-羟色胺水平均明显低于空白对照组(P<0.01),与模型组比较,冠心静组及氟西汀组均能改善大鼠的旷场试验评分,增加体重,提高糖水偏爱得分及5-HT水平(P<0.05),2组间比较无明显统计学意义。结论:冠心静胶囊可以改善心梗后抑郁大鼠的行为学表现及5-HT水平,其治疗双心疾病的作用值得进一步研究。

Objective： To observe the effects of Guanxinjing（ GXJ） capsule on behavioral phenomenon of post-myocardial infarction depression model rats. Methods： Model was induced by chronic mild and unpredictability stress after coronary artery ligation in rats,and behavior index of rats as well as the level of 5-HT before and after treatment was measured respectively. Results： The score of horizontal and vertical motion score,weight,rate of liquid consumption,sucrose preference test score and level of 5-HT in model group were significantly lower than blank control group（ P 0. 01）. Compared with model group,the GXJ capsule group and fluoxetine group can improve the score of open field test,increase the body weight of rats,and improve the sucrose preference test score as well as the level of 5-HT（ P 0. 05）. There was no significant difference between the two groups. Conclusion： GXJ capsule can improve behavioral manifestations and 5-HT level of post-myocardial infarction depression model rats. Further study on GXJ capsule treating psycho-Cardiological disease is worthy to go on.