青海地区更年期综合征发病机制及证候特点的相关研究

Study on Pathogenesis and Syndrome Characteristics of Syndrome in Qinghai Province

目的:探讨青海地区更年期综合征发病机制及证候特点。方法:选取青海省泽库县、民和县、西宁市3个地区的符合《中药新药绝经前后诸证临床研究指导原则(试行)》诊断标准的患者各200例,根据更年期综合征患者的主要临床症状、舌象、脉象来分型,采集血液性激素六项、全血黏度、T淋巴细胞亚群数值进行比较。结果:1)本课题调查结果显示以肾阴虚为主,高海拔地区的肾阳虚、肾阴阳两虚、心肾不交较多,而肾虚肝郁型人数较少;2)青海不同海拔地区更年期综合征患者性激素水平与海拔有相关性,高海拔地区FSH、LH较其他地区明显高,E_2水平较低;3)血液流变学指标与海拔梯度相关,高海拔地区血液黏稠度较其他地区明显升高;4)T淋巴细胞亚群的比较三者之间无明显统计学意义。结论:1)青海地区更年期综合征以肾阴虚为主,海拔较高处肾阳虚、肾阴阳两虚、心肾不交较海拔低处多见;2)高海拔地区卵巢功能较其他地区明显低下;3)高海拔地区血液黏稠度较其他地区明显高,考虑高原低氧可能是患者血液黏稠度增高的原因,并推断高原低氧导致卵巢功能低下,或是血液黏稠度影响卵巢功能,因此通过滋肾宁心、温通化瘀,能改变血流变,提高卵巢功能,从而更好的改善青海地区更年期患者症状。

Objective： To explore menopausal syndrome pathogenesis and syndrome characteristics of women in Qinghai province.Methods： Collect 200 cases from Zeku,Minhe,Xining counties respectively in Qinghai province which conform to TCM Clinical Research Guiding Principles for Pre and After Menopause Disorders（ try out）. Compare tongue image and pulse six sex hormones,whole blood viscosity,and T lymphocyte subsets among them. Results： 1） The subject survey is given priority to kidney Yin deficiency. In high altitude areas,the majority of people has kidney yang deficiency,kidney dual deficiency and imbalance of kidney and heart syndromes,only a minority group of people has kidney deficiency and liver stagnation. 2） Sex hormone levels has high correlation with altitude,FSH,LH levels are significantly higher in high altitude areas and the level of E_2 is lower. 3） The blood rheology indexes related to elevation gradient,high altitude blood viscosity obviously higher than other areas. 4） The T lymphocyte subgroup no significant statistical differences the comparison between of the three. Conclusion： 1） The qinghai region menopausal syndrome with kidney Yin deficiency is given priority to. Elevation is high Kidney Yang deficiency and kidney Yin and Yang are two empty. heart kidney is not handed in The lower altitudes. 2） High altitude ovarian function obviously lower than other regions. 3） Blood viscosity is significantly higher in high altitude regions,low oxygen may be the reason behind it. Also,blood viscosity may affect ovarian function so by nourishing kidney and calming heart,and warmly regulating and removing stasis,menopausal symptoms can be improved.