帕金森病^(18)F-FDG PET成像研究进展

^(18)F-FDG PET imaging in Parkinson's disease

帕金森病是一种常见的神经系统变性疾病,早期诊断和鉴别诊断历来是神经科临床工作的难点之一,随着功能影像学的发展,^(18)F-氟脱氧葡萄糖(FDG)正电子发射断层扫描成像(PET)成为帕金森病临床诊疗中的重要工具。本文回顾了目前^(18)F-FDG PET成像常用数据分析方法及帕金森病临床症状和脑代谢之间的研究结果 ,并对^(18)F-FDG PET成像在帕金森病的鉴别诊断、早期诊断和疗效评估以及未来发展方向进行综述。

Parkinson＇s disease is a common neurological degenerative disease, early diagnosis and differential diagnosis are the most difficult points toneurologist. With the development of functional imaging,^18F labelled fluorodeoxyglucose（FDG） positron emission tomography（PET） imaging has become an important tool for Parkinson＇s disease. This artical first review the current analytic approaches to ^18F-FDG PET imaging data and then discuss how ^18F-FDG PET studies have advanced understanding of the relation between the clinical symptoms and brain metabolism of Parkinson＇s disease. In addition,the value of ^18F-FDG PET imaging in differential diagnosis, early diagnosis,the evaluation of treatment effects and the future development direction are also reviewed.