颅内动脉瘤再出血危险因素的研究进展

Research progress in risk factors for rebleeding of intracranial aneurysms

颅内动脉瘤再出血是导致动脉瘤性蛛网膜下腔出血(a SAH)患者不良预后的严重并发症,可导致患者的高死亡率和高伤残率。再出血的机制受到许多复杂因素的共同作用。最近几十年的研究已经确定了一些危险因素与再出血有关,如治疗延误、收缩压变化、动脉瘤大小、纤溶作用、较差的神经系统状态、血肿量、先兆头痛等,但一些因素尚存争议,如基因、性别、动脉瘤位置等。本文对导致再出血危险因素的研究进展以及当前对再出血的防治措施进行综述。

Intracranial aneurysm rebleeding is a serious complication leading to poor prognosis in patients with aneurysmal subarachnoid hemorrhage.It can lead to high mortality and high disability in patients.The mechanism of rebleeding is influenced by many complex factors.Recent decades of research have identified a number of risk factors associated with rebleeding,such as treatment delay,changes in systolic blood pressure,aneurysm size,fibrinolysis,poor neurological status,hematoma volume,sentinel headache Etc.However,some factors remain controversial,such as genes,sex,aneurysmlocation and so on.This review summarizes the research progress of the risk factors leading to rebleeding and the current prevention of rebleeding.