H型高血压患者代谢性相关指标及MTHFR基因多态性分析

Analysis of metabolic related indexes and MTHFR gene polymorphism in patients with H-type hypertension

目的分析MTHFR基因在高血压患者中的多态性,探讨H型高血压与同型半胱氨酸(Hcy)等代谢性生化指标的关系。方法选取2013年7月~2016年6月我院收治的100例H型高血压患者和100例普通高血压患者为研究对象,检测两组的血浆同型半胱氨酸(Hcy)和血脂、血糖等生化指标,比较MTHFR基因多态性。结果 H型高血压组的Hcy、尿酸(UA)、肌酐(Cr)水平明显高于普通高血压组(t=14.989、6.672、4.832,P<0.05);H型高血压组的MTHFR 677C/T基因型频率分布以T等位基因为主,普通高血压组以C等位基因频率分布为主(P<0.05)。结论高Hcy、UA、Cr水平与H型高血压的发生密切相关,MTHFR基因677C/T纯合突变TT基因型可能是H型高血压的重要遗传因素。

Objective To analyze the polymorphism of MTHFR gene in patients with hypertension,and to explore the relationship between H-type hypertension and metabolic biochemical indexes such as homocysteine（Hcy）.Methods 100 patients with H-type hypertension and 100 patients with general hypertension treated in our hospital from July 2013 to June 2016 were selected as study subjects.Plasma homocysteine（Hcy） and blood lipids,blood glucose and other biochemical indicators were detected in two groups,and the polymorphism of MTHFR gene was compared.Results Hcy,uric acid（UA）,creatinine（Cr） level in the H-type hypertension group were significantly higher than those in the general hypertension group（t=14.989,6.672,4.832,P〈0.05）.The frequency di stribution of MTHFR 677C/T genotype frequency of the H-type hypertension group was mainly T allele,and the frequency distribution of C allele was dominant in the general hypertension group（P〈0.05）.Conclusion The level of Hcy,UA and Cr are closely related to the occurrence of Htype hypertension.Homozygous mutant TT genotype of MTHFR gene 677C/T may be an important genetic factor of Htype hypertension.