胰岛自身抗体和生化指标在糖尿病分型诊断中的应用价值

The application value of insulin autoantibodies and biochemical indexes in the type diagnosis of diabetes mellitus

目的分析探讨针对糖尿病患者检测抗胰岛素抗体、抗胰岛细胞抗体、抗谷氨酸脱羧酶抗体的临床应用价值。方法选取我院2013年8月~2016年8月收治的临床DM患者230例作为研究对象,检测患者的抗胰岛素抗体、抗胰岛细胞抗体、抗谷氨酸脱羧酶抗体。根据抗体阴性/阳性分为T1DM组和T2DM组,分别比较两组的空腹葡萄糖、空腹胰岛素及空腹C肽浓度。结果 T1DM组患者的IAA-Ab、ICA-Ab以及GAD-Ab阳性率明显高于T2DM组,差异有统计学意义(P<0.05)。IAA-Ab、ICA-Ab以及GAD-Ab阳性组和阴性组的空腹胰岛素浓度比较,差异有统计学意义(P<0.05),空腹葡萄糖和空腹C-肽比较,差异无统计学意义(P>0.05)。结论糖尿病患者检测自身抗体,对糖尿病的早期诊断、分型和治疗有很大的指导意义。

Objective To analyze and discuss the clinical application value of detection islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies in the diagnosis of diabetes mellitus.Methods 230 cases of clinical diabetes mellitus patients admitted to our hospital from August 2013 to August 2016 were selected as the study subjects.The indexes of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies were detected.The T1 DM group and T2 DM group were divided according to antibody negative/positive classification,the FBG,INS and CP concentrations of two groups were observed.Results The positive rate of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of patients in T1 DM group was significantly higher than that in T2 DM group,and the differences were statistically significant（P〈0.05）.The INS concentrations of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of positive group and negative group were compared,and the differences were statistically significant（P〈0.05）;the indexes of FBG and CP of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of positive group and negative group were compared,and the difference was not statistically significant（P〉0.05）.Conclusion For diabetes mellitus patients,the detection of insulin autoantibodies have great guiding significance in the early diagnosis,typing and treatment.