神经酰胺在非酒精性脂肪性肝病发生发展中的作用

Role of ceramide in development and progression of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征。"二次打击"学说可以部分解释NAFLD的发病机制。神经酰胺是NAFLD发生发展中关键的分子信使,而且其作为一种鞘脂与"二次打击学说"密切相关。对神经酰胺在NAFLD中的作用进行了综述。

Nonalcoholic fatty liver disease（ NAFLD） is a clinicopathological syndrome caused by liver damage factors except alcohol and has the major feature of diffuse macrovesicular hepatocyte steatosis. The ＂ two-hit ＂ hypothesis can partly explain the pathogenesis of NAFLD. Recent studies have found that ceramide is a key molecular messenger involved in the development and progression of NAFLD,and as a sphingolipid,it is closely associated with the ＂ two-hit＂ hypothesis. This article reviews the role of ceramide in NAFLD.