microRNA调控胰腺星状细胞活化对慢性胰腺炎纤维化进程的影响

Effect of pancreatic stellate cell activation regulated by microRNA on fibrosis of chronic pancreatitis

慢性胰腺炎是一种进行性的慢性炎症性疾病,最终表现为不可逆的胰腺纤维化。其诊断及治疗困难,且目前无有效延缓或逆转纤维化的手段。介绍了microRNA(miRNA)在慢性胰腺炎纤维化中所起作用的研究进展,认为胰腺星状细胞的活化是胰腺纤维化的关键步骤。miRNA可通过改变基因表达,介导信号通路、上皮-间充质转化进程等,调控胰腺星状细胞的活化,参与慢性胰腺炎纤维化的进展,其有望成为慢性胰腺炎治疗的新靶点。

Chronic pancreatitis is a progressive chronic inflammatory disease and finally progresses to irreversible pancreatic fibrosis. The diagnosis and treatment of chronic pancreatitis is difficult and there are still no effective measures for delaying or reversing fibrosis. This article introduces the research advances in the role of microRNA（ miRNA） in the fibrosis of chronic pancreatitis and points out that pancreatic stellate cell activation is the key step in pancreatic fibrosis. Recent studies have demonstrated that miRNA regulates pancreatic stellate cell activation and participates in the fibrosis of chronic pancreatitis through altering gene expression and mediating signaling pathways and epithelial-mesenchymal transition,and miRNA may become a new target for the treatment of chronic pancreatitis.