甲状腺癌患者血清Gal-3、IL-17、IL-35、anti-TgAb的变化及其意义

Significance of serum Gal-3,IL-17,IL-35 and anti-TgAb in patients with thyroid carcinoma

目的:探讨甲状腺癌患者血清半乳凝酸-3(Gal-3)、白细胞介素-17(IL-17)、白细胞介素-35(IL-35)、抗甲状腺球蛋白抗体(anti-TgAb)水平的变化及其临床意义。方法:选取我院2013-01~2015-12确诊的甲状腺癌患者129例为甲状腺癌组,另选同期甲状腺腺瘤患者40例为对照组,检测并比较两组血清Gal-3、IL-17、IL-35、anti-TgAb水平,并对甲状腺癌患者根据病理结果进行亚组分析。结果:甲状腺癌组血清Gal-3、IL-17、anti-TgAb水平均高于对照组,IL-35水平低于对照组,差异具有统计学意义(P<0.05);甲状腺乳头状癌、甲状腺滤泡状癌患者血清Gal-3、IL-17、anti-TgAb水平均低于甲状腺未分化癌患者,IL-35水平高于甲状腺未分化癌患者,差异具有统计学意义(P<0.05);甲状腺乳头状癌患者血清Gal-3、IL-17、anti-TgAb水平均低于甲状腺滤泡状癌患者,IL-35水平高于甲状腺滤泡状癌患者,差异具有统计学意义(P<0.05)。结论:甲状腺癌患者血清Gal-3、IL-17、IL-35、anti-TgAb水平发生显著的改变,并且与病理类型具有一定的关系,对于临床诊断及鉴别诊断具有一定的参考价值。

Objective： To investigate the changes and clinical significance of serum galectin 3 （Gal-3） ,interleukin-17 （IL- 17）, interleukin- 35 （IL- 35）, anti thyroglobulin antibody （anti-TgAb） levels in patients with thyroid carcinoma.Methods： A total of 129 patients with thyroid carcinoma admitted from January 2013 to December 2015 were selected as thyroid carcinoma group,then 40 cases with thyroid adenoma were selected as the control group. The serum levels of Gal- 3, IL- 17, IL- 35, anti- TgAb, and thyroid carcinoma patients according to the pathological results of the subgroup analysis were detected and compared. Results： The serum Gal-3, IL-17 and anti-TgAb levels in thyroid carcinoma group were higher than those in the control group, the serum level of IL-35 were lower than control group, the difference was statistically significant （P〈 0.05）. The serum Gal - 3, IL - 17, anti - TgAb in papillary thyroid carcinoma, thyroid follicular carcinoma patients were lower than that of undifferentiated thyroid carcinoma, and serum level of IL- 35 was higher than that in undifferentiated thyroid carcinoma, the difference was statistically significant （P 〈0.05）. The serum Gal-3,IL-17 and anti-TgAb in papillary thyroid carcinoma patients were lower than those in follicular thyroid carcinoma patients,the serum IL-35 level was higher than that in follicular thyroid carcinoma patients, the difference was statistically significant （P 〈 0.05）. Conclusion ： The levels of serum Gal- 3, IL- 17, IL- 35, anti- TgAb in patients with thyroid carcinoma are significantly changed, and has certain relationship with the pathological types. It has certain reference value for clinical diagnosis and differential diagnosis.