经尿道前列腺电切术与钬激光前列腺剜除术的疗效比较

Comparison of TURP and HoLEP in treatment of benign prostatic hyperplasia

目的:对比经尿道前列腺电切术(TURP)与钬激光前列腺剜除术(HoLEP)的临床疗效。方法:2015-02~2016-12收住212例合并膀胱出口梗阻(BOO)的良性前列腺增生症(BPH)患者,随机分为两组,分别行HoLEP(HoLEP组,n=108)和TURP(TURP组,n=104)治疗,比较两组患者围术期的相关指标。结果:两组手术均顺利完成。HoLEP组术后血钠、血红蛋白下降水平、住院时间、拔管时间均低于TURP组,切除增生的前列腺组织质量多于TURP组(P<0.05),差异有统计学意义;但两组平均手术时间比较,差异无统计学意义(P>0.05)。随访3~22个月,两组术后3个月的国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Qmax)、残余尿量(RUV)均较术前明显改善(P<0.05),组间比较无统计学差异(P>0.05)。结论:HoLEP与TURP治疗前列腺增生症短期疗效相当,但HoLEP具有出血少、恢复快、残留腺体少,并发症少等优点。

Objective：To compare the clinical efficacy of holmium laser enucleation of prostate （HoLEP） and transurethral resection of prostate （TURP） in treatment of benign prostatic hyperplasia （BPH）.Methods：A total of 212 patients with BPH admitted during February 2015 and December 2016 were divided into HoLEP group （n=108） and TURP （n= 104） according to treatment.Clinical indexes were detected and analyzed during perioperative period between two groups.Results：The operation was completed successfully.The level of serum sodium and hemoglobin （Hb）,hospital stays,extubation time in HoLEP group were lower than those in TURP group,the weight of resected prostate tissues was more than TURP group （P〈0.05）, the differences was statistically significant, while the average operation time was not statistically significant （P〉0.05）.The quality of life score （QOL）,maximum uripary flow rate （Qmax） and residual urine volume （RUV） were significantly improved compared with before operation （P〈0.05） after 3--22 months follow--up. Conclusion： HoLEP and TURP have a similar short--term efficacy in the treatment of BPH.HoLEP has advantages of less bleeding, faster recovery, fewer complications,and is a good treatment option.