奥美拉唑联合伊托必利治疗反流性食管炎的临床疗效研究

Clinical effect of omeprazole combined with itopride in treating reflux esophagitis

目的探讨奥美拉唑联合伊托必利治疗反流性食管炎的临床疗效。方法选取攀枝花市仁和区人民医院2014年9月—2016年7月收治的反流性食管炎患者156例,随机分为对照组和研究组,每组78例。对照组患者采用法莫替丁联合伊托必利治疗,研究组患者采用奥美拉唑联合伊托必利治疗,两组患者均持续治疗2个疗程。比较两组患者治疗前后临床症状(呕吐恶心、反酸、胸口烧灼感)积分及临床疗效,观察患者药物不良反应发生情况。结果治疗前,两组患者呕吐恶心、反酸、胸部烧灼感积分比较,差异无统计学意义(P>0.05);治疗后,研究组患者呕吐恶心、反酸、胸部烧灼感积分低于对照组(P<0.05)。研究组患者总有效率高于对照组(P<0.05)。两组患者治疗期间均未发生药物不良反应。结论采用奥美拉唑联合伊托必利治疗反流性食管炎的临床疗效确切,可有效改善患者的临床症状,且安全性高。

Objective To study the clinical effect of omeprazole combined with itopride in treating reflux esophagitis.Methods A total of 156 cases of patients with reflux esophagitis were selected from September 2014 to July 2016 in District People＇s Hospital of Panzhihua City,which were randomly divided into control group and study group,78 cases in each group. The control group was treated with famotidine combined with itopride,study group was treated with omeprazole combined with itopride,both groups were treated for 2 courses. The clinical symptoms（ vomiting,acid reflux and chest burning） scores before and after treatment,clinical efficacy were compared between the two groups,and the incidence of adverse reactions were observed. Results Before treatment,no significant differences of vomiting,acid reflux or chest burning scores was found between the two groups（ P〉0. 05）; after treatment,the study group of vomiting,acid reflux and chest burning scores were lower than control group（ P〈0. 05）. The total effective rate of study group was higher control group（ P〈0. 05）. No adverse reactions was observed between the two groups. Conclusion Omeprazole combined with itopride have an obviously clinical effect in treating reflux esophagitis,it can improve the clinical symptoms of patients,and with high safety.