不同程度慢性阻塞性肺病患者血栓前状态临床分析

Clinical Analysis of Prethrombotic State of Patients with Chronic Obstructive Pulmonary Disease of Different Degrees

目的探讨对不同程度慢性阻塞性肺病患者血栓前状态分析的临床意义。方法方便选取该院2014年1月—2016年8月期间收治的60例慢性阻塞性肺病患者,根据患者肺功能结果分为轻度A组20例,中度B组20例及重度及极重C组20例,同时选择20名健康体检者作为对照组,比较各组凝血指标差异。结果 A组、B组、C组的HB分别为(141.4±14.6)、(145.2±15.7)、(148.2±11.5)g/L,D-D分别为(0.4±0.1)、(1.9±0.3)、(2.5±0.1)mg/L,FIB分别为(2.8±0.2)、(3.7±0.6)、(4.1±0.4)g/L,与对照组比较差异有统计学意义(P<0.05);各组在APTT、PLT及PT方面比较差异无统计学意义(P>0.05)。结论不同程度慢性阻塞性肺病患者血栓前状态存在一定的差异,其病程程度越重,血栓前状态更加显著。

Objective To study the clinical significance of prethrombotic state of patients with chronic obstructive pulmonary disease of different degrees. Methods Convenient selection 60 cases of patients with chronic obstructive pulmonary disease admitted and treated in our hospital from January 2014 to August 2016 were selected and divided into three groups with 20 cases in each, including the mild A group, moderate B group and severe C group, and 20 cases of healthy physical examination people were selected as the control group, and the difference in the coagulation index between the two groups was compared. Results The HB in the group A, group B and group C was respectively(141.4±14.6),(145.2±15.7),(148.2±11.5)g/L, and the D-D and FIB were respectively(0.4±0.1),(1.9±0.3),(2.5±0.1)mg/L and(2.8±0.2),(3.7±0.6),(4.1±0.4)g/L,and the differences were obvious(P<0.05), and the differences in the APTT,PLT and PT among groups were not statistically significant(P>0.05). Conclusion There is a certain difference in the prethrombotic state of patients with chronic obstructive pulmonary disease of different degrees, with the severer of diseases, the prethrombotic state is more obvious.