顿服与分次服用美沙拉嗪缓释颗粒剂治疗轻中度活动期溃疡性结肠炎的疗效、安全性和依从性对比分析

Comparative Analysis of Curative Effect, Safety and Compliance of Oral Administration at Draught and Fractionated Administration of Mesalazine Granular Controlled-release Formulation in Treatment of Mild to Moderate Active Ulcerative Colitis

目的研究分析美沙拉嗪缓释颗粒剂顿服与次服治疗轻、中度活动期溃疡性结肠炎(UC)的疗效、安全性和依从性。方法方便该院在2015年1—12月期间收治的111例轻中度活动期溃疡性结肠炎患者纳入研究对象,随机分为对照1组、对照2组(各37例)和观察组(37例),给予对照1组、对照2组分别次服美沙拉嗪缓释颗粒剂2次/d,2 g/次与4次/d,1 g/次,给予观察组口服该药1次/d,4 g/次,均治疗12周后比较两组患者治疗效果、安全性及用药依从性的情况。结果观察组治疗总有效率94.59%同对照1组总有效率91.89%及对照2组总有效率89.19%比较差异无统计学意义(P>0.05),观察组与对照组患者黏膜治愈率比较差异无统计学意义(P>0.05);观察组用药依从性(100.00%)明显高于对照1组(86.49%)、对照2组(78.38%)(P<0.05)。结论美沙拉嗪缓释颗粒剂不同的用药方式治疗效果相同,顿服的用药方式明显的提高了患者的用药依从性,值得临床药效推广。

Objective To research the curative effect, safety and compliance of oral administration at draught and fractionated administration of mesalazine granular controlled-release formulation in treatment of mild to moderate active ulcerative colitis. Methods 111 cases of patients with f mild to moderate active ulcerative colitis admitted and treated in our hospital from January to December 2015 were convenient selected and randomly divided into the control 1 group, control 2 group and observation group with 37 cases in each, the control 1 group and control 3 group adopted the fractionated administration of mesalazine granular controlled-release formulation 2 times daily, 2 g every time and 4 times daily and 1 g every time,the observation group adopted the oral administration of the drug once every day, 4 g every time, after 12-week treatment,the treatment effect, safety and medication compliance were compared between the two groups. Results There was no obvious difference in the total effective rate between the observation group, control 1 group and control 2 group,(94.59%,91.89%, 89.19%)(P>0.05), and there was no obvious difference in the mucous membrane cure rate between the observation group and the control group(P>0.05), and the medication compliance in the observation group was obviously higher than that in the control 1 group and control 2 group(100.00% vs 86.49%, 78.38%)(P<0.05). Conclusion The treatment effect of different medication methods for mesalazine granular controlled-release formulation is the same, and the oral administration at draught can obviously improve the medication compliance, and it is worth clinical promotion.