结直肠癌骨转移临床特点的Meta分析

The clinical features of bone metastasis of colorectal cancer,A meta-analysis

目的探讨结直肠癌原发肿瘤位置及淋巴结分期与骨转移发生率的相关性。方法计算机检索万方数据库、清华同方全文数据库(CNKI)、维普数据库、Pubmed、Ovid、EMBASE及Medline等数据库,对符合纳入标准的文献应用RevMan 5.0软件进行Meta分析,同时按照不同原发部位以及淋巴结转移状态对各分析结果的OR值及95%CI进行计算。结果共纳入文献10篇,总样本量21 702例,其中直肠癌患者11 529例,结肠癌患者10 173例。Meta分析结果显示,直肠癌与结肠癌相比,骨转移发生率增高,OR值为1.91,95%CI为1.65~2.21;淋巴结阳性患者较淋巴结阴性患者更容易出现骨转移,OR值为3.22,95%CI为2.09~4.96。结论原发肿瘤位置和淋巴结转移状态与骨转移发生率相关。直肠癌以及淋巴结阳性患者更容易出现骨转移。

Objective To explore the relationship between the incidence of bone metastasis and primary tumor location or lymph node stage for colorecatal carcinoma. Methods A systematic search was performed in Wanfang database,CNKI,Pubmed,Ovid,EMBASE and Medline.A meta-analysis was performed to generate the OR and 95%CI for the relationship using Review Manager 5.0.Results A total of 10 studies and 21 702 cases were enrolled in this meta-analysis.Our findings indicated that the patients with rectal cancer had a higher incidence of bone metastasis than the patients with colon cancer,the ORand 95%CI was 1.91 and 1.65-2.21.The patients with positive lymph node had a higher incidence of bone metastasis than the patients with negative lymph node,the OR was 3.22,and 95%CI was 2.09-4.96.ConclusionPrimary tumor location and lymph node stage were associated with the incidence of bone metastasis.