西酞普兰治疗冠心病合并焦虑抑郁患者的疗效观察

Effect observation of Citalopram on patients with coronary heart disease complicated with anxiety and depression

目的:观察西酞普兰治疗冠心病合并焦虑抑郁患者的疗效。方法:将126例冠心病合并焦虑抑郁患者随机分为对照组和观察组,各63例。对照组实施常规治疗,观察组实施常规治疗并服用西酞普兰。评价两组汉密尔顿抑郁量表(HAMD)评分及血清超敏C-反应蛋白(hsCRP)水平、心血管事件和不良反应发生情况。结果:治疗后,观察组HAMD评分及血清hsCRP水平、心血管事件发生率均比对照组低(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:在常规治疗基础上,采用西酞普兰治疗冠心病合并焦虑抑郁的疗效优于单纯常规治疗疗效。

Objective To observe effects of Citalopram in treatment of coronary heart disease w’ith anxiety and depression. Methods： One hundred and twenty-six patients with coronar heart disease and anxiety and depression were randomly divided into control group （ n = 63） and observation group （ n = 63）. The patients in the control group were treated with conventional therapy, while those in the observation group received routine treatment and Citalopram. The HAMD score, serum high-sensitivity C-reactive protein （hsCRP） , cardiovascular events and adverse events of the two groups were evaluated. Results： After the treatment, the HAMD score, the serum hsCRP level and the incidence of cardiovascular events in the observation group were lower than those in the control group （ P 〈0.05）. There was no significant difference in incidence of adverse reactions between the two groups （ P〉0.05）. Conclusions ： Cita- lopram based on the conventional therapy in the treatment of coronary heart disease with anxiety and depression is superior to single conventional therapy.