摘要
针对孕母及胎儿生长的动态变化规律,建立了通过孕母口服地高辛治疗胎儿快速心律失常的药物动力学模型,根据胎龄变化及临床上地高辛的治疗窗口所反映的血药浓度,设计了合理的用药方案,并运用MATLAB程序进行应用模拟,分析了方案的可行性.
In this paper, according to the dynamic change regulation of pregnant mother and fetus growth, a pharmacokinetic model of maternal fetal oral digoxin in the treatment of tachyarrhythmia is established, reasonable regimens on the basis of the gestational age changes and the digoxin therapeutic window of clinical react blood drug concentration are designed, and MATLAB program for simulation, analysising the feasibility of the scheme is used.
出处
《高校应用数学学报（A辑）》
CSCD
北大核心
2017年第3期343-352,共10页
Applied Mathematics A Journal of Chinese Universities(Ser.A)
基金
黑龙江省自然科学基金(A2016004)
