性激素检验在不孕症诊断中的价值

Clinical study on the effect of sex hormone test in the diagnosis of infertility

目的分析性激素检验不孕症的临床诊断效果。方法随机选取2015年3月—2016年11月收治的48例女性不孕症患者,将其设为研究组;选取同期参与体检的48名女性健康者作为对照组。检测研究组和对照组的性激素水平包括催乳素(PRL)、卵泡刺激素(FSH)、孕酮(P)、雌二醇(E2)、黄体生成素(LH)以及睾酮(T),并采用t检验分析,以P<0.05为差异有统计学意义。结果研究组的PRL、P和T水平分别为(431.5±132.9)ng/ml、(2.1±1.8)ng/ml、(0.9±0.3)ng/ml显著高于对照组(319.2±103.5)ng/ml、(1.5±0.7)ng/ml、(0.5±0.2)ng/ml,差异有统计学意义(均P<0.05);而研究组的FSH和E2水平[(4.1±1.9)m IU/ml、(38.5±31.5)pg/ml]则显著低于对照组[(6.7±2.1)m IU/ml、(69.3±41.9)pg/ml],差异有统计学意义(均P<0.05);研究组LH水平[(4.4±3.1)m IU/ml]与对照组[(4.3±3.0)m IU/ml]比较,差异无统计学意义(P>0.05)。结论不孕症诊断过程中,通过检验性激素水平,掌握PRL、FSH、P、E2和T水平,可为临床诊断提供指导作用。

Objective To analyze the clinical effect of sex hormone test in the diagnosis of infertility. Methods Forty eight cases of female infertility patients collected from March 2015 to December 2016 were selected as the observation group, and 48 healthy patients were regarded as the control group. The sex hormone levels, including prolactin（PRL）, follicle stimulating hormone（FSH）, progesterone（P）, estradiol（E2）, luteinizing hormone（LH） and testosterone（T） were determined and analyzed. Measurement data uses t test and count data uses χ~2 test. P〈0.05 is considered statistically significant. Results Levels of PRL, P and T in the observation group[（431.5±132.9） ng/ml,（2.1±1.8） ng/ml,（0.9±0.3） ng/ml] were significantly higher compared with the control group [（319.2±103.5） ng/ml,（1.5±0.7） ng/ml,（0.5±0.2） ng/ml]（all P〈0.05）. Levels of FSH and E2 [（4.1±1.9） m IU/ml,（38.5±31.5） pg/ml] were significantly lower than that of the control group [（6.7±2.1） m IU/ml,（69.3±41.9） pg/ml]（all P〈0.05）. There was no significant difference in LH level between the observation group（4.4±3.1） m IU/ml and the control group（4.3±3.0） m IU/ml（P〈0.05）. Conclusion Determining the levels of PRL, FSH, P, E2 and T can be used as a clinical guidance in the course of infertility diagnosis. It is worthy of extensive application.