肠道菌群与炎症性肠病

Gut Microbiota and Inflammatory Bowel Diseases

炎症性肠病(inflammatory bowel diseases,IBD)主要指溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD)。IBD的发病机制尚未明确,有研究认为各种环境因素作用于遗传易感者,在肠道菌群的参与下,启动肠道免疫系统及非免疫系统,最终诱发肠道产生炎症反应。与正常人相比,IBD患者的肠道存在不同程度的菌群失调,此文就肠道菌群在IBD发病中的作用及其治疗中的应用作一综述。

Inflammatory bowel diseases( IBD) mainly refers to the ulcerative colitis( UC) and Crohn's disease( CD). At present,the pathogenesis of IBD has not been clear,considering the effect of various environmental factors on genetic susceptibility. The presence of gut microbiota activate intestinal immune system and non immune system,inducing intestinal inflammatory reaction through a variety of mechanisms. Compared with the normal people,there are different degrees of gut microbiota imbalance in IBD patients. This article reviews the role of gut microbiota in the pathogenesis of IBD and its application in the treatment of the diseases.