右美托咪定预处理对肝缺血再灌注损伤预防保护作用

Protective Effects of Dexmedetomidine Preconditioning on Hepatic Ischemia Reperfusion Injury of Liver Function

目的:证实右美托咪定预处理对肝缺血再灌注损伤是否具有保护作用。方法:选择择期在全麻下行肝部分切除术的患者60例,随机分为右美托咪定预处理组和0.9%氯化钠盐水预处理组,分别在阻断前,阻断结束时,术后第1天(T2),术后第三天测定血浆AST,ALT,TNF-α,IL-6的水平。结果:右美托咪定预处理组血浆AST,ALT,TNF-α,IL-6术后各时间段升高水平均低于对照组,差异均有统计学意义(P<0.05)。结论:小剂量右美托咪定持续泵入对肝门阻断后缺血再灌注损伤具有一定的预防作用。

Objective： To confirme dex preconditioning on hepatic ischemia reperfusion injury has protective effect. Methods： 60 cases of undergoing partial liver resection patients were selected. Respectively in the block before,after blocking,on the first day after operation,after the third day determination of plasma levels of ALT,AST,TNF-α,IL-6 levels. Results： In dex group,the plasa level of AST,ALT,TNF-α,IL-6 were lower than the control group at. each period. Conclusion： Small dose dexmedetomidine continuous infusion on hepatic portal occlusion after ischemia reperfusion injury has a certain preventive effect.