局部枸橼酸抗凝在连续性肾脏替代治疗中的应用

Application of Local Citrate Anticoagulation in Continuous Renal Replacement Therapy

目的:研究局部枸橼酸抗凝在连续性肾脏替代治疗中的应用。方法:选取我院收治的46例行连续性肾脏替代治疗的危重症患者为研究对象,分为局部枸橼酸抗凝组(RCA组)和无抗凝剂组。其中局部枸橼酸抗凝组28例患者,无抗凝剂组18例患者。结果:两组在滤器使用寿命上的比较RCA组明显长于无抗凝剂组,对比差异有统计学意义(P<0.05)。结论:局部枸橼酸抗凝在连续性肾脏替代治疗中的应用,能够通过延长滤器使用寿命以提高治疗效果,提高连续性肾脏替代治疗的安全性。

Objective： To study the application of local citrate anticoagulation in continuous renal replacement therapy. Methods： 46 critically ill patients treated with continuous renal replacement therapy in our hospital were selected as subjects. They were divided into local citrate anticoagulant group（ RCA group） and no anticoagulant group. Among them,28 cases of local citrate anticoagulation group,18 patients without anticoagulant group. Results： The two groups in the filter life comparison,RCA group was significantly longer than the no anticoagulant group,difference the statistically significant was（ P 0. 05）. Conclusion： Local citrate anticoagulation in continuous renal replacement therapy,can prolong service life of the filter in order to improve the therapeutic effect,improve the safety of continuous renal replacement therapy.