穴位贴敷联合穴位注射对慢性阻塞性肺疾病急性加重期患者T淋巴细胞的影响

Effect of acupoint-application combined with acupoint-injection on T-lymphocyte changes in AECOPD patients

目的观察穴位贴敷联合穴位注射对慢性阻塞性肺疾病急性加重期患者外周血及肺泡灌洗液T淋巴细胞的影响。方法将80例患者按照随机数字表法分为两组,各40例。对照组给予西医常规治疗联合肺泡灌洗,治疗组在对照组治疗基础上给予穴位贴敷、穴位注射治疗。观察两组患者治疗前后临床症状、外周血及肺泡灌洗液CD+4、CD+8、CD+4/CD+8变化,分析比较两组临床疗效。结果 (1)治疗组与对照组临床疗效判定无差异,P>0.05;(2)外周血T淋巴细胞:治疗组,治疗前后外周血中CD+4、CD+8、CD+4/CD+8,均有明显差异,P<0.01。治疗后,治疗组CD+4、CD+4/CD+8,比对照组均升高,P<0.05,CD+8下降,P<0.05,有显著差异。(3)肺泡灌洗液T淋巴细胞:治疗后,治疗组CD+4、CD+4/CD+8均较对照组升高,CD+8较对照组下降,P<0.05,有显著差异。结论慢性阻塞性肺疾病急性加重期患者经治疗后,患者症状均能改善,通过穴位贴敷联合穴位注射疗法,能调节患者的免疫功能,增强机体抵抗力。

Objective To observe the effect of acupoint-application combined with acupoint-injection on T- lymphocyte changes in blood and bronchoalveolar lavage fluid of AECOPD patients. Methods 80 AECOPD patients were divided randomly into two groups ： the therapy group （ n = 4 0 ） and the control group （ n = 4 0 ） . Both groups were treated with conventional Western medicine and bronchoalveolar lavage. In addition, acupoint-application com-bined with acupoint-injection was provided for the therapy group. Their clinical symptoms and T-lymphocyte changes were observed and the clinical efficacy was compared. Results （ 1） There was no significant difference in the effica-cy between the two groups after treatment （P 〉 0. 05） . （ 2 ） There was significant difference in C D ：、 CDg＋、 C D ： / CD8＋ before and after treatment in the therapy group （ P 〈 0. 01）. The value of CD4＋ and CD4＋/CD8＋ increased and CD8＋ decreased more obviously in the therapy group and the control group after treatment （ P 〈 0. 05 ） . Conclusion Acupoint-application combined with acupoint-injection can improve efficacy, as well as enhance immune function and the body resistance of AECOPD patients.