粘连性肠梗阻患者经奥曲肽治疗对其肠黏膜功能的影响探析

Analysis of Effect of Octreotide Treatment of Patients with Adhesive Ileus on the Intestinal Mucosa Function

目的探讨应用奥曲肽对粘连性肠梗阻患者进行治疗的临床效果及对患者肠黏膜功能产生的影响。方法随机选取2014—2016年该院收治的32例粘连性肠梗阻患者,按照随机数字法分为两组,对照组给予常规治疗,观察组加用奥曲肽进行治疗,对比两组疗效及肠黏膜功能变化情况。结果观察组总有效率为93.75%,显著高于对照组的75.00%(P<0.05);治疗后,观察组血清内毒素、D-乳酸水平分别为(0.20±0.03)EU/m L、(9.67±2.28)μg/m L,均显著低于对照组的(0.29±0.063)EU/m L、(14.23±2.53)μg/m L(P<0.05)。结论加用奥曲肽对粘连性肠梗阻患者进行治疗,可使患者肠黏膜屏障功能得到更大程度改善,总体疗效更佳。

Objective To study the effect of octreotide treatment of patients with adhesive ileus on the intestinal mucosa function. Methods 32 cases of patients with adhesive ileus admitted and treated in our hospital from 2014 to 2016 were randomly selected and randomly divided into two groups, the control group adopted the routine therapy, while the observation group added the octreotide for treatment on the basis of the control group, and the changes of curative effect and intestinal mucosa function were compared. Results The total effective rate in the observation group was obviously higher than that in the control group,(93.75% vs 75.00%),(P<0.05), after treatment, the serum endotoxin and D-lactic acid levels in the observation group were obviously lower than those in the control group, [(0.20 ±0.03)EU/m L],(9.67 ±2.28)μg/m L] vs(0.29 ±0.063)EU/m L,(14.23 ±2.53)μg/m L],(P <0.05). Conclusion The octreotide treatment of patients with adhesive ileus can obviously improve the intestinal barrier function, and the total curative effect is good.