低分子右旋糖酐、低分子肝素联合治疗短暂性脑缺血发作的疗效及2年随访结果调查

Curative Effect of Low Molecular Dextran and Low Molecular Heparin in Treatment of Transient Ischemic Attack and Investigation of Two-year Follow-up Results

目的探讨低分子右旋糖酐联合低分子肝素治疗短暂性缺血发作的疗效,并随访调查2年复发情况。方法方便选择该院2013年1月—2014年12月收治的102例短暂性脑缺血发作患者为研究对象,随机数字法将其分为两组,各51例,均接受改善脑循环、抗血小板聚集、原发病对症处理等基础治疗,在此基础上对照组给予低分子右旋糖酐治疗,观察组患者则行低分子右旋糖酐联合低分子肝素治疗,对两组临床疗效、不良反应、治疗前后实验室指标、2年复发率进行比较。结果观察组治疗有效率、2年复发率分别为96.1%、4%,与9对照组的68.6%、16%比较差异有统计学意义(P<0.05)。另外,两组治疗后PT[(14.6±1.9)s VS(11.0±2.1)s]、PLT[(162.1±31.9)×109/L VS(221.2±39.2)×109/L]、APTT[(40.6±2.9)s VS(35.1±2.1)s]及FIB[(3.3±1.0)g/L VS(3.8±1.2)g/L]比较,差异有统计学意义(P<0.05)。结论低分子右旋糖酐联合低分子肝素治疗TIA近远期疗效良好,复发率低,安全可靠。

Objective To study the curative effect of low molecular dextran and low molecular heparin in treatment of transient ischemic attack and investigation of two-year follow-up results. Methods 102 cases of patients with transient ischemic attack admitted and treated in our hospital from January 2013 to December 2014 were convenient selected and randomly divided into two groups with 51 cases in each, both groups adopted the basic treatment of improving the cerebral circulation,anti-platelet aggregation and symptomatic treatment of primary disease, and the control group were treated with low molecular dextran on the basis of the basic treatment, and the observation group were treated with low molecular dextran and low molecular heparin, and the clinical curative effect, adverse reactions and laboratory indexes before and after treatment and2-year recurrence rate were compared between the two groups. Results The treatment effective rate and 2-year recurrence rate in the observation group and in the control group were respectively 96.1% 、4% and 68.6% 、16%, and the differences were obvious(P<0.05), besides, the PT、PLT、APTT after treatment between the two groups were statistically significance,[(14.6 ±1.9)s VS(11.0 ±2.1)s], [(162.1 ±31.9) ×109/L VS(221.2 ±39.2) ×109/L] and [(40.6 ±2.9)s VS(35.1 ±2.1)s] and FIB[(3.3±1.0)g/L VS(3.8±1.2)g/L](P<0.05). Conclusion The short-term and long-term curative effects of low molecular dextran and low molecular heparin in treatment of transient ischemic attack and investigation of two-year follow-up results are good with low recurrence rate, and it is safe and reliable.