溶组织羧菌胶原酶治疗阴茎硬结症:一种新的微创有效的治疗方法

Collagenase clostridium histolyticum for Peyronie's disease:A new minimally invasive and effective treatment

阴茎硬结症的治疗一直是困扰患者和泌尿男科医师的难题。目前口服药物多数被认为无效,剩下的方法需要严格掌握适应症,有的尚存争议。而最终的手术治疗则可能伴发阴茎缩短或勃起功能障碍等并发症。溶组织羧菌胶原酶被证实能够有效溶解阴茎海绵体斑块的作用,被美国食品药品管理局批准成为第一个用于治疗阴茎硬结症的药物。本文旨在介绍这种新的阴茎硬结症治疗方式的特点、安全性、有效性及治疗方法。以期让更多的泌尿男科大夫和患者受益。

The treatment of Peyronieg disease has been a challenge to urologists, as most of the current oral medications are con- sidered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may he associated with complications such as penile shortening or erectile dysfunction. Collagenase elostridium histolyti- cure has been proved to be effective in dissolving the penile eavemosal plaque and approved by the Food and Drug Administration of the USA as the first drug to he used for the treatment of Peyronieg disease. This article presents an introduction to the characteristics, safe- tv. efficacy, and nroeednres of this new treatment, which may benefit urologists and the patients with Peyronie＇s disease.