非嵌合型Klinefelter综合征患者显微取精术研究进展

Microdissection testicular sperm extraction for patients with non-mosaic Klinefelter's syndrome:An update

Klinefelter综合征(KS)是男性最常见的性染色体异常疾病,第二性征发育迟滞或不发育及不育是其最常见临床表现。随着现代辅助生殖技术的发展,KS患者拥有自己遗传学意义后代成为可能。显微睾丸取精术(m TESE)是公认的最佳取精术式,本文就其预测指标、取精成功率、手术方法、术后并发症、术前性激素替代治疗及术后睾酮下降等问题进行综述。

Klinefelter＇s syndrome （KS） is a most frequent sex chromosomal disorder in males, which is characterized by hypogo- nadism and infertility. The development of assisted reproductive technology has made it possible for KS males to father children. Micro- dissection testicular sperm extraction （mTESE） is widely considered to be the best method for sperm retrieval in KS patients. This arti- cle presents an overview on mTESE for men with non-mosaic KS in the aspects of its predictors, sperm retrieval rate, operation proce- dure, preoperative hormonal therapy, and postoperative complications and testosterone reduction. Natl J Androl, 2017, 23 （9） ： 842 - 847